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Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study

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By Katherine Hoffman, Grace Marshall, Collrane Frivold, Zack Acker, Isabel Arnould, Melissa Briggs-Hagen, Amanda M. Casto, Erica Clark, Sarah Cox, Mark Hamilton Drummond, Brenna Ehmen, Janet A Englund, Luis Gamboa, Alexander L. Greninger, Sally B. Grindstaff, Peter Han, Tara L. Hatchie, Jennifer L. Kuntz, Natalie Lo, christine lockwood, Carter McCormick, Melissa MacMillan, Claire M. Midgley, Daniel Nguyen, Ian D. Plumb, Jonathan Reed, Pavitra Roychoudhury, Mark Schmidt, Lea M. Starita, Jeremy Stone, Alexandra Varga, Ana A. Weil, Charles J Wolock, Peter Gilbert, Allison L. Naleway, Helen Y. Chu, Marco Carone, Sarina R. Barnes, Hanna Grioni, Madison Hollcroft, Kaden D. McAllister, Sacha Reich, Neil Yetz
| Nature Verified
Abstract Few studies have characterized immune correlates of SARS-CoV-2 infection risk in children, particularly those with hybrid immunity from vaccination and prior infection. We conduct a prospective community-based cohort study of 1509 U.S. children (2022–2024), performing weekly SARS-CoV-2 PCR testing and measuring baseline binding and neutralizing antibody titers against multiple variants.
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