Christopher Barton

1 Introduction Removing host cell protein (HCP) impurities is a principal goal of downstream processing for biotherapeutics, and purification processes routinely employ multiple orthogonal chromatography and filtration steps to promote their removal and to meet industry and regulatory expectations for residual HCP content (Gilgunn and Bones 2018; Y. Li 2017; Pezzini et al. 2011; Shukla and Hinckley 2008; Shukla et al. 2007).

1 Introduction Removing host cell protein (HCP) impurities is a principal goal of downstream processing for biotherapeutics, and purification processes routinely employ multiple orthogonal chromatography and filtration steps to promote their removal and to meet industry and regulatory expectations for residual HCP content (Gilgunn and Bones 2018; Y. Li 2017; Pezzini et al. 2011; Shukla and Hinckley 2008; Shukla et al. 2007).

4.1.4 Experimental methodology The methodology follows these steps: (1) Compile each benchmark, for each platform, with aggressive optimization flags (see Section 4.1.2) using the six strategies: Intrinsic, Tiling, Tiling+Packing, PLuTo, BLAS, and Eigen. (2) Create a list containing all of the executables. (3) Measure the execution time of each element of the list once. (4) Randomize the list of executables before the next set of measurements.