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Christopher Chester on Muck Rack

Christopher Chester

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1231 W Radcliff Ave, Englewood, CO 80110, US

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By Christopher Chester
| BiggerPockets Verified
The content relating to real estate for sale in this Web site comes in part from the Internet Data eXchange (“IDX”) program of METROLIST, INC., DBA RECOLORADO® Real estate listings held by brokers other than are marked with the IDX Logo. This information is being provided for the consumers’ personal, non-commercial use and may not be used for any other purpose. All information subject to change and should be independently verified.
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SOX2 empowers a rapid tumorigenic programme from the tumour resistant population in the skin

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By Patricia P. Centeno, Christopher Chester, Catriona A. Ford, Rachel A. Ridgway
| BioRxiv
Abstract The skin undergoes continuous renewal, relying on stem and progenitor cells to maintain its barrier function. Over time, multiple oncogenic and tumour suppressor events accumulate. How the skin tolerates these mutations in different populations and how cutaneous squamous cell carcinoma (cSCC) emerges from mutant clones is poorly understood. Rapid cSCC development can ensue in melanoma patients treated with BRAF inhibitors (BRAFi) through paradoxical activation of RAF signalling.
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Epidermal tumour-resistant progenitors require SOX2-driven developmental reprogramming to drive tumorigenesis

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By Patricia P. Centeno, Christopher Chester, Catriona A. Ford, Rachel A. Ridgway
| BioRxiv
Abstract The epidermal basal layer consists of two distinct progenitor populations contributing differentially to skin homeostasis or wound healing. However, their resilience to oncogenic insults is unknown. Here, we developed mouse models allowing lineage tracing and oncogene expression in both populations. Our findings support the existence of two long-lived and functionally distinct epidermal progenitors and define them as tumour-primed and tumour-resistant.
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