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Articles by Christopher Cotter
Traumatic brain injury and post-injury sleep fragmentation differentially alter the microglial transcriptome
1 Introduction Traumatic brain injury (TBI) is a major source of injury-related death and disability, affecting more than 20 million individuals every year (1). Medical advances have led to a decline in TBI-related deaths, but this contributes to a growing population of survivors who suffer chronic injury-related consequences that can persist for several years after injury. Many of these chronic issues are perpetuated by neuroinflammation and mediated by microglia (2–4).
Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy
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Keywords HCC molecular subtype liver cell lineages atezolizumab bevacizumab immunotherapy mechanisms of response and resistance Introduction Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and the fourth most lethal.1 Combination immunotherapy with atezolizumab and bevacizumab has become a new standard of care as the first-line therapy for unresectable HCC by demonstrating strong antitumor activity in an initial phase 1b study (GO30140)2 and subsequently superior...
By Yulei Wang, Yinghui Guan, Alexander Abbas, Yuji Sano, Saket Jain, Shan Lu, Habib Hamidi, Hartmut Koeppen, Alekhya Pochiraju, Joshua Webster, Christopher Cotter, Stephen P Hack, Edward Cha, Takahiro Ishiguro, Josep M Llovet, Andrew Zhu, Richard Finn, Yumiko Azuma, Yoko Kayukawa, Junko Shinozuka, Natascha Rieder, Gabriele Dietmann, Michael Cannarile
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Cell Reports Medicine
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Correspondent Banking, Systemic Risk, and the Panic of 1893
For much of its history, the U.S. banking system consisted of fragmented unit banks operating in single locations. This structure required banks to form complex correspondent networks to facilitate the movement of capital and the clearing of payments across space and time.
CRISPR-GRIT: Guide-RNAs with Integrated Repair Templates Enable Precise Multiplexed Genome Editing in the Diploid Fungal Pathogen Candida albicans
Abstract Candida albicans is an opportunistic fungal pathogen that causes severe infections in immunocompromised individuals. Overuse of antifungals coupled with climate change has led to the rapid emergence of antifungal resistance. Thus, there is an urgent need to understand fungal pathogen genetics to develop new antifungal strategies. Genetic manipulation of C. albicans is encumbered by its diploid chromosomes which require editing both alleles for elucidating gene function.
Inkton v. Family Dollar et al
Plaintiff: Antonio Inkton Defendant: Family Dollar, Family Dollar Services LLC and Michael Jacobs Case Number: 1:2023cv01638 Filed: August 23, 2023 Court: US District Court for the Northern District of Ohio Presiding Judge: Patricia A Gaughan Nature of Suit: P.I.: Other Cause of Action: 28 U.S.C. ยง 1441 Petition for Removal- Personal Injury Jury Demanded By: Both RSS Track this Docket This docket was last retrieved on August 23, 2023. A more recent docket listing may be available from PACER.
Evaluating the Antioxidant Properties of the Ancient-Crop Tef (Eragrostis tef) Grain Extracts in THP-1 Monocytes
1. Introduction An imbalance between the production of reactive oxygen species (ROS) and their elimination by antioxidants results in oxidative stress [1]. Under normal physiological conditions, ROS, including superoxide anions (O2•−), hydrogen peroxide (H2O2), and hydroxyl radicals (•OH), act as regulators of cellular signaling pathways [2].
Potency of CRISPR-Cas Antifungals Is Enhanced by Co-targeting DNA Repair and Growth Regulatory Machinery at the Genetic Level
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Proteomes Reveal Metabolic Capabilities of Yarrowia lipolytica for Biological Upcycling of Polyethylene into High-Value Chemicals
New Results doi: https://doi.org/10.1101/2023.04.17.537167 Abstract Polyolefins derived from plastic wastes are recalcitrant for biological upcycling. However, chemical depolymerization of polyolefins can generate depolymerized plastic (DP) oil comprising of a complex mixture of saturated, unsaturated, even and odd hydrocarbons suitable for biological conversion. While DP oil contains a rich carbon and energy source, it is inhibitory to cells.
Oak Cliff Recycling, Inc. v. Dade Auctions, Inc.
Oak Cliff Recycling, Inc. v. Dade Auctions, Inc. Plaintiff: Oak Cliff Recycling, Inc. Defendant: Dade Auctions, Inc. Case Number: 3:2023cv00399 Filed: February 28, 2023 Court: US District Court for the Northern District of Ohio Nature of Suit: Other Statutes: Arbitration Cause of Action: 28 U.S.C. § 1331 Fed. Question Jury Demanded By: None RSS Track this Docket Docket Report This docket was last retrieved on February 28, 2023. A more recent docket listing may be available from PACER.
When Religion Is Not Religion: Inside Religious Studies’ Fight for Religious Literacy in the Public Sphere
After wrapping up a Q&A session at a public conference where I presented on the topic of Islam and Christian-Muslim relations to a largely evangelical Christian audience, an older man who was sitting in the back approached me at the podium.
Agent-Based Modeling Reveals Possible Mechanisms for Observed Aggregation Cell Behaviors: Aggregation of Myxococcus xanthus
Myxococcus xanthus is a soil bacterium that serves as a model system for biological self-organization. Cells form distinct, dynamic patterns depending on environmental conditions. An agent-based model (ABM) was used to understand how M. xanthus cells aggregate into multicellular mounds in response to starvation. In this model, each cell is modeled as an agent, represented by a point-particle and characterized by its position and moving direction.
Your View: The Hannigan name belongs on new South End school
By Christopher Cotter I am writing to express my opposition to renaming the John Hannigan Elementary School in New Bedford's South End. There is no reason whatsoever to rename a school that is being built on the same site of a school. Sadly, it appears the mayor has lost sight of those who worked hard for this city and represented this city with honor.For those who don’t know who John Hannigan was, here is what he did for the city, and what the city of New Bedford meant to him.
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