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Christopher E. Barbieri on Muck Rack

Christopher E. Barbieri

As seen in: Nature, Genome Biology, European Urology, UroToday, Journal of Interventional Radiology (JVIR)
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Articles

BPTF regulates androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction - Nature Communications

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By Hee-Young Jeon, Sudeep Khadka, Hung-Ming Lam, Eva Corey, Htoo Zarni Oo, Xiaofang Che, Christopher E. Barbieri
| Nature Verified
Abstract BPTF, the scaffolding subunit of the nucleosome remodeling factor (NURF) complex, has been implicated in the progression of several malignancies, but its role in prostate cancer (PCa) remains unclear. Here, we demonstrate that BPTF is upregulated in castration-resistant prostate cancer (CRPC) and promotes disease progression. RNA-seq revealed that BPTF primarily enhances the expression of androgen receptor (AR) target genes.
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Direct measurement of the male germline mutation rate in individuals using sequential sperm samples - Nature Communications

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By Jonathan E. Shoag, Caitlin A Loh, Emilie Lassen, Benjamin Costa, Christopher E. Barbieri, Anne-Bine Skytte, Anyull D. Bohorquez, Pamela Callum
| Nature Verified
Abstract Mutations that accumulate in the human male germline with age are a major driver of genetic diversity and contribute to genetic diseases. However, aging-related male germline mutation rates have not been measured directly in germline cells (sperm) at the level of individuals. We developed a study design in which we recalled 23 sperm donors with prior banked samples to provide new sperm samples.
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Canonical Androgen Response Elements in Prostate Cancer Growth Suppression - Christopher Barbieri

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By Christopher E. Barbieri
| UroToday Verified
Read the Full Video Transcript Andrea Miyahira: Hi. I'm Andrea Miyahira at the Prostate Cancer Foundation. With me is Dr. Christopher Barbieri of Weill Cornell Medicine, who will present a recent Nature Communications paper, "Canonical Androgen Response Element Motifs are Tumor Suppressive Regulatory Elements in the Prostate." Thanks, Dr. Barbieri for joining and sharing this. Christopher Barbieri: Thanks. It's a pleasure to be here with you today.
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