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Christopher E. Barbieri on Muck Rack

Christopher E. Barbieri

As seen in: Nature, Genome Biology, European Urology, UroToday, Journal of Interventional Radiology (JVIR)
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Articles

Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism

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By Zhongchi Li, Shuchen Liu, Leyi Xiao, Nayah Bullen, Xuanrong Chen, Jude N. Owiredu, Zhucui Li, Rabia Khan, Jennifer E. Endress, Moniquetta Shafer, Vivien Low, Sungyun Cho, Christopher E. Barbieri, Chun-Jun Guo, John Blenis, Wenbing Jin, Olivia Kester, Nikolaos Koundouros
| Nature Verified
Abstract Enhanced cholesterol synthesis and lipid droplet accumulation are hallmarks of aggressive prostate cancer, yet how tumour cells sense metabolic inputs to dynamically regulate cholesterol homeostasis remains poorly defined. Here we uncover a metabolic signalling mechanism in which prostate cancer cells remodel propionyl-CoA metabolism to support stress adaptation during disease progression.
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BPTF regulates androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction - Nature Communications

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By Hee-Young Jeon, Sudeep Khadka, Hung-Ming Lam, Eva Corey, Htoo Zarni Oo, Xiaofang Che, Christopher E. Barbieri
| Nature Verified
Abstract BPTF, the scaffolding subunit of the nucleosome remodeling factor (NURF) complex, has been implicated in the progression of several malignancies, but its role in prostate cancer (PCa) remains unclear. Here, we demonstrate that BPTF is upregulated in castration-resistant prostate cancer (CRPC) and promotes disease progression. RNA-seq revealed that BPTF primarily enhances the expression of androgen receptor (AR) target genes.
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Direct measurement of the male germline mutation rate in individuals using sequential sperm samples - Nature Communications

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By Jonathan E. Shoag, Caitlin A Loh, Emilie Lassen, Benjamin Costa, Christopher E. Barbieri, Anne-Bine Skytte, Anyull D. Bohorquez, Pamela Callum
| Nature Verified
Abstract Mutations that accumulate in the human male germline with age are a major driver of genetic diversity and contribute to genetic diseases. However, aging-related male germline mutation rates have not been measured directly in germline cells (sperm) at the level of individuals. We developed a study design in which we recalled 23 sperm donors with prior banked samples to provide new sperm samples.
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