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Nayah Bullen on Muck Rack

Nayah Bullen

As seen in: Nature, Science Magazine
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Articles

Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism

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By Zhongchi Li, Shuchen Liu, Leyi Xiao, Nayah Bullen, Xuanrong Chen, Jude N. Owiredu, Zhucui Li, Rabia Khan, Jennifer E. Endress, Moniquetta Shafer, Vivien Low, Sungyun Cho, Christopher E. Barbieri, Chun-Jun Guo, John Blenis, Wenbing Jin, Olivia Kester, Nikolaos Koundouros
| Nature Verified
Abstract Enhanced cholesterol synthesis and lipid droplet accumulation are hallmarks of aggressive prostate cancer, yet how tumour cells sense metabolic inputs to dynamically regulate cholesterol homeostasis remains poorly defined. Here we uncover a metabolic signalling mechanism in which prostate cancer cells remodel propionyl-CoA metabolism to support stress adaptation during disease progression.
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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By Lianjie Miao, Nikos Koundouros, Michal J. Nagiec, Nayah Bullen
| Science Magazine Verified
Research Article SIGNAL TRANSDUCTION Science 14 Mar 2025 Vol 387, Issue 6739 Access the full article View all access options to continue reading this article. Supplementary Materials MDAR Reproducibility Checklist References and Notes 1 S. G. Kim, G. R. Buel, J. Blenis, Nutrient regulation of the mTOR complex 1 signaling pathway. Mol. Cells 35, 463–473 (2013). 2 R. A. Saxton, D. M. Sabatini, mTOR Signaling in Growth, Metabolism, and Disease. Cell 168, 960–976 (2017). 3 G. Lee, Y. Zheng, S. Cho, C. Jang, C.
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