Christopher Frederick Mugler

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Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate

Nov 29, 2018 |

By Ze Cheng, Abdurrahman Keskin, Christopher Frederick Mugler, Stefanie Hodapp

| Cell Press

Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels.

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Christopher Frederick Mugler

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Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate

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