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Christopher L Barkau on Muck Rack

Christopher L Barkau

As seen in: The Journal of Biological Chemistry
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Articles

Binding to the Conserved and Stably Folded Guide RNA Pseudoknot Induces Cas12a Conformational Changes During Ribonucleoprotein Assembly

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By Sruthi Sudhakar, Christopher L Barkau, Southern Illinois, Ramadevi Chilamkurthy
| The Journal of Biological Chemistry Verified
INTRODUCTION Conformational changes are the basis of protein and RNA folding from long biopolymers into biologically active molecules ( 1 Moran, L. A., Horton, H. R., Scrimgeour, K. G., and Perry, M. D. (2012) Principles of Biochemistry, 5th ed., Pearson ). The affinity, specificity, and stability of molecular interactions often scales with buried surface area (or number of molecular contacts) and the degree of surface complementarity ( ).
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Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States

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By Adrian A Pater, Michael S Bosmeny, Christopher L Barkau, Katy N Ovington
| BioRxiv
New Results Adrian A. Pater, Michael S. Bosmeny, Christopher L. Barkau, Katy N. Ovington, Ramadevi Chilamkurthy, Mansi Parasrampuria, Seth B. Eddington, Abadat O. Yinusa, Adam A. White, Paige E. Metz, Rourke J. Sylvain, Madison M. Hebert, Scott W. Benzinger, Koushik Sinha, View ORCID ProfileKeith T. Gagnon doi: https://doi.org/10.1101/2021.01.11.426287 Abstract Genomic virus surveillance can lead to early identification of new variants and inform proper response during a pandemic.
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