1 1Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia; 2Department of Chemistry, University of Colorado, Boulder, Colorado 80309, USA; 3Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA Corresponding author: hpickett{at}cmri.org.au ↵4 These authors contributed equally to this work. Footnotes Supplemental material is available for this article.