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Chunkou Yin on Muck Rack

Chunkou Yin

As seen in: Nature, Stem Cell Reports
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Articles

Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human

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By Luqin Wang, Lizhan Xiao, Huiping Mao, Shihao Zhang, Qiusheng Yang, Chunkou Yin, Jiani Wan, MANISH Kumar, Haokaifeng Wu, Haoxian Wang, Xiaoli Zhang, Lihua Zeng, Chunhua Zhou, Shengyong Yu, Yi Li, Lingling Zheng, Yuliang Liu, Baojian Liao, Zhen Zhang, Jing Liu, Gaoyang Zou
| Nature Verified
Abstract Rebuilding human naïve pluripotency from primed stem cells is essential for generating pre-implantation epiblast-like cells, a key source for regenerative medicine. Here we present a defined, feeder-free protocol that efficiently converts primed human pluripotent stem cells (hPSCs) to a naïve-like state within 12 days.
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Dose-resolved control of somatic reprogramming by Rora

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By Haiyun Wang, Yusha Li, Zhen Zhang, Yixuan Wang, Yi Li, Chuang Li, Runxia Lin, Xiaoli Zhang, Jing Guo, Rongping Luo, Shumin Li, Lizhan Xiao, Bailing Chen, Shengyong Yu, MANISH Kumar, Jing Liu, Chunkou Yin, Lv Zhang, Yingting Zhuang, Anchun Xu, Jiani Wan
| Stem Cell Reports Verified
Keywords Rora nuclear receptors somatic cell reprogramming dose-dependent regulation Introduction Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) by transcriptional factors resets cell identity but remains constrained by cell-intrinsic barriers and incomplete control of chromatin and signaling (Chen et al., 2011; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wang et al., 2019).
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