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Dose-resolved control of somatic reprogramming by Rora
Keywords Rora nuclear receptors somatic cell reprogramming dose-dependent regulation Introduction Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) by transcriptional factors resets cell identity but remains constrained by cell-intrinsic barriers and incomplete control of chromatin and signaling (Chen et al., 2011; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wang et al., 2019).
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