Chunying Li
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Prenatal Ultrasound and MRI in the Diagnosis of a Rare Fetal Dysplastic Megalencephaly Caused by AKT1 Gene Variant
1 Introduction Dysplastic megalencephaly is a rare disorder characterized by hamartomatous overgrowth of the cerebral hemispheres and severe cortical malformations (Del Campos Braojos and Guimaraes 2018), which may be accompanied by abnormalities in other organ systems. This condition may be accompanied by abnormalities in other organ systems.
Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke : The INSTANT Randomized Clinical Trial
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Key Points Question Among patients with acute ischemic stroke without large or medium vessel occlusion or cardioembolic source, does intravenous tirofiban after an insufficient response to intravenous tenecteplase improve functional outcomes?
By Xianghong Liu, fan zhang, Cong Zhang, Zongliang Li, Guangxiong Yuan, Deyan Kong, Shuhua Xie, Min Zhou, Jinchun Ye, Zhaohui Lai, Dan Li, Hailong Xu, Lei Chen, Fangqun Cheng, Bin Chen, Weihua Hu, Huashi Liu, Yi Yin, Zhiyong Xie, Chunying Li, Junfeng Shi, Bin Liu, Bo Wang, Ruize Zhou, Jingjing Liu, Limin Shen, Hairong Hu, Xiaoyu Guan, Xunwei Lv, Xiang zeng, Yi Chen, Wenfeng Cao, Chong Zheng, Junda Li, Baozhu Guan, Wei Sun, Hongliang Zeng, Jian Zhang, Shizhan Li, Hongfei Sang, Yamei Tang, Duolao Wang, Mengjie Lu, Johannes Kaesmacher, Vignan Yogendrakumar, Raul G. Nogueira, Daojun Hong, Mayank Goyal, Götz Thomalla, Thanh Nguyen, Jeffrey L. Saver, Qingwu Yang, Zhongming Qiu, Xinbo Deng, Donghuan Mei, Genxiang Xiao, Shanggui Yuan, Shuiping Liang, Yuanlu Liu, Tianmin Lai, Suyue Pan, Guoyong Zeng
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JAMA: Journal of the American Medical Association
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GSDME acts as an epigenetic modifier to promote melanoma development via centriole biogenesis regulator PLK4
Abstract Gasdermins have been traditionally recognized for their canonical pore-forming activity in pyroptosis and generally considered as a tumor suppressor due to their low endogenous expression in various types of cancers. However, the pyroptosis-independent role of gasdermins in cellular biological processes remains poorly understood, sparking debates on their actual contribution to cancer pathogenesis.
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