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Chwen-Lih Chen

As seen in: Nature
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Articles

Genetic or pharmacological inhibition of hepatic TMEM141 attenuates MASH and fibrosis via the ROS-HNF4α signaling pathway

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By Jiayou Wang, Chwen-Lih Chen, Raja Gopoju, Shuwei Hu, Yang Wang, Hui Wang, Xiaoli Pan, Yeong-Renn Chen, Jeffrey G. Mellott, Patrick Kang, Liya Yin, Yanqiao Zhang, Zaid Batayneh, Lakshitha Gunawardana
| Nature Verified
Abstract Metabolic dysfunction-associated steatoic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis (MASH), have become a global epidemic due to obesity and genetic susceptibility. Here, we report transmembrane protein 141 (TMEM141), a protein with a largely unknown function, as a key regulator of MASH and MASH-associated fibrosis. Hepatic TMEM141 is reduced in MASLD/MASH patients and mouse models of MASLD/MASH due to increased microRNA-149.
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Mitochondrial redox regulation and myocardial ischemia-reperfusion injury

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By Liwen Zhang, Zhicheng Jin, Takhar Kasumov, Chwen-Lih Chen
| American Physiological Society
ThemesTheme: Mitochondrial Biology in Health, Aging, and Disease Chwen-Lih Chen, Liwen Zhang, Zhicheng Jin, Takhar Kasumov, and Yeong-Renn Chen Abstract Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system.
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