Chyuan-Sheng Lin

Abstract Recent studies have revealed many alternative exons differentially spliced across diverse neuron types in the mammalian brain, but their links to neuronal physiology remain unclear. Here we characterize a deeply conserved microexon E35a in Ank3 encoding ankyrin-G (AnkG), a multifaceted adaptor protein best known as a master organizer of the axon initial segment (AIS) and as a leading genetic risk factor for bipolar disorder.

Correction to: Nature https://doi.org/10.1038/s41586-024-08542-2 Published online 5 February 2025 In the version of this article originally published, the author Takeshi Takarada (Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) was not listed and is now included in the HTML and PDF versions of the article. About this article Fang, Y., Chung, S.S.W., Xu, L. et al.

Abstract A hallmark of pulmonary fibrosis is the aberrant activation of lung fibroblasts into pathological fibroblasts that produce excessive extracellular matrix1,2,3. Thus, the identification of key regulators that promote the generation of pathological fibroblasts can inform the development of effective countermeasures against disease progression.