Submitted: 15 October 2025 You are already at the latest version Background: Heart failure (HF) affects over 64 million people globally, imposing substantial morbidity, mortality, and economic burdens. Despite advances in guideline-directed therapies, adherence remains suboptimal due to low health literacy and complex regimens. ChatGPT, an advanced large language model by OpenAI, offers conversational capabilities that could enhance HF education, management, and research.