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Cindy A Evandy

As seen in: BioRxiv, Cell Reports
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Articles

Damage-induced pyroptosis drives endogenous thymic regeneration via induction of Foxn1 by purinergic receptor activation

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By Sinéad Kinsella, Cindy A Evandy, Kirsten Cooper, Antonella Cardinale
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Attenuation of apoptotic cell detection triggers thymic regeneration after damage

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By Sinéad Kinsella, Cindy A Evandy, Kirsten Cooper, Lorenzo Iovino
| Cell Reports Verified
Highlights • NOD2 suppresses the production of the key thymic regenerative factors BMP4 and IL-23 • Detection of apoptotic thymocytes by TAM receptors mediates NOD2-dependent suppression • Depletion of thymocytes after acute damage attenuates detection of apoptotic cells • Inhibition of Rac1 promotes thymus repair and T cell reconstitution after damage Summary The thymus, which is the primary site of T cell development, is particularly sensitive to insult but also has a remarkable capacity...
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Attenuation of homeostatic signaling from apoptotic thymocytes triggers a global regenerative response in the thymus

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By Sinéad Kinsella, Kirsten Cooper, Lorenzo Iovino, Cindy A Evandy
| BioRxiv
New Results View ORCID ProfileSinéad Kinsella, Cindy A Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C deRoos, Kayla S Hopwo, David W Granadier, Colton W Smith, Shahin Rafii, Jarrod A Dudakov doi: https://doi.org/10.1101/2020.08.31.275834 Abstract The molecular triggers of organotypic tissue repair are unknown.
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