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Cinzia Bessone

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Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5 + tumor stem cell lineage commitment upon Wnt depletion

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By Feng Jiang, Antoine Diez, Juncheng Yao, Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone, Maritta Räisänen, Inkeri Vuori, Davide G. Berta, Johanna Aspholm, Tatiana V. Petrova, Lauri A Aaltonen, Kari Alitalo, Pauliina Kallio
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Plasticity, the capability of tumor cells to go through phenotypic transitions, promotes colorectal cancer (CRC) progression and treatment resistance. Although plasticity is evident in advanced CRCs, little is known about plasticity in early-stage tumors and tumor stem cells.
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