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Pauliina Kallio

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Articles

Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5 + tumor stem cell lineage commitment upon Wnt depletion

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By Feng Jiang, Antoine Diez, Juncheng Yao, Marika Lassila, Fatemeh Seyednasrollah, Cinzia Bessone, Maritta Räisänen, Inkeri Vuori, Davide G. Berta, Johanna Aspholm, Tatiana V. Petrova, Lauri A Aaltonen, Kari Alitalo, Pauliina Kallio
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Plasticity, the capability of tumor cells to go through phenotypic transitions, promotes colorectal cancer (CRC) progression and treatment resistance. Although plasticity is evident in advanced CRCs, little is known about plasticity in early-stage tumors and tumor stem cells.
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Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma - Communications Biology

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By Pauliina Kallio, Teijo Pellinen, Caroline Heckman, Harri Mustonen, Kari Alitalo, Olli Kallioniemi, Tuomas Mirtti, Vilja Pietiäinen, Matilda Roos-Mattila, Katja Välimäki
| Nature Verified
Abstract Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor (TKI) sensitivity have been reported in PM-ccRCC. However, no functional or single-cell studies have been conducted thus far.
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Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation

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By Pauliina Kallio, of Helsinki, Elina Jokinen, Jenny Högström
| cancerres.aacrjournals.org
Tumor Biology and Immunology Pauliina Kallio, Elina Jokinen, Jenny Högström, Suvendu Das, Sarika Heino, Marianne Lähde, Jefim Brodkin, Emilia A. Korhonen and Kari Alitalo DOI: 10.1158/0008-5472.CAN-20-0497 Published June 2020 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Abnormal vasculature in tumors leads to poor tissue perfusion and cytostatic drug delivery.
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