Clea Bárcena

Darío Pescador El envejecimiento no tiene una sola causa, sino muchas que influyen unas en otras, y pueden combatirse haciendo cambios en nuestro estilo de vida Creatina: los mitos sobre el suplemento de moda que se resisten a desaparecer ¿Por qué envejecemos? Muchas veces la respuesta a esta pregunta es tautológica: envejecemos porque nuestro organismo se deteriora, y nuestro organismo se deteriora porque nos hacemos mayores. Pero envejecer es mucho más que cumplir años.

Abstract Autophagy is a housekeeping catabolic process crucial for maintaining cell, tissue and organism functions. Through the years, the study of animal models with tissue-specific inactivation of autophagy essential genes has allowed us to understand its protective roles in the context of multiple human diseases, including cancer and neurodegeneration. However, due to the essential nature of autophagy, the effects of its systemic inhibition in mammals have not been explored in detail.

Correction to: Nature Genetics https://doi.org/10.1038/s41588-023-01472-1, published online 24 August 2023. In the version of the article initially published, grants to L.M. from the Associazione Italiana per la Ricerca sul Cancro (AIRC) (grant 20125; AIRC 5x1000 project 21267) and Cancer Research UK, FC AECC and AIRC under the International Accelerator Award Program (C355/A26819 and 22796) were missing from the Acknowledgments section.