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Clinical Metabolomics

As seen in: Wiley Online Library, Oxford University Press (OUP), Frontiers, Cell Reports
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Articles

Correlation between serum prolactin and the systemic immune-inflammation index in diabetic kidney disease: a cross-sectional study

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By Clinical Metabolomics
| Frontiers
Abstract Objective: Prolactin (PRL) is increasingly recognized as a pleiotropic hormone with potent immunoregulatory properties; however, its involvement in systemic inflammation among diabetic kidney disease (DKD) patients has not been defined. This study aimed to investigate the potential association between serum PRL levels and micro-inflammation in patients with DKD. Methods: In this cross-sectional investigation, 994 patients with type 2 diabetes mellitus (T2DM)-associated DKD were enrolled.
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Causal Inference of Different Smoke Exposure Statuses and Influenza Risk: Insights From a Mendelian Randomization Study

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By Yanqi Guo, Haixia Chen, Shijie Wu, Clinical Metabolomics
| Wiley Online Library Verified
1 Introduction Influenza is an acute viral infection that primarily targets the respiratory system and spreads rapidly between individuals [1]. The World Health Organization reports that seasonal influenza affects nearly one billion people worldwide each year, with 3 to 5 million cases classified as severe. This illness leads to an estimated 290 000 to 650 000 respiratory-related deaths annually [2].
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MSU crystal deposition contributes to inflammation and immune responses in gout remission

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By Clinical Metabolomics
| Cell Reports Verified
Highlights • Systemic inflammation in remission gout with MSU crystal deposition is observed • HLA-DQA1high CD14+ monocytes boost immune responses and bone erosion in advanced gout • CD8+ T cells are overactivated in remission gout at intercritical and advanced stage • Upregulation of PTGS2 in monocyte subtypes promotes AA metabolism in advanced gout Summary As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout flares, but its impact on immune inflammation in...
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