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Colin W. Pouton on Muck Rack

Colin W. Pouton

Victoria
As seen in: Nature, Sydney Morning Herald, The Conversation, Antena 3, The Age, Royal Society of Chemistry, Medical Xpress, Brisbane Times, WAtoday, Down To Earth and
Professor of Pharmaceutical Biology at @MIPS_Australia, @MonashPharm.
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Articles

A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles - Nature Nanotechnology

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By Moore Z. Chen, Daniel Yuen, Cameron Smyth, Stewart A Fabb, Patrick Sexton, Colin W. Pouton
| Nature Verified
Abstract Efficient and precise delivery of mRNA is critical to advance mRNA therapies beyond their current use as vaccines. Lipid nanoparticles (LNPs) efficiently encapsulate and protect mRNA, but non-specific cellular uptake may lead to off-target delivery and minimal delivery to target cells. Functionalizing LNPs with antibodies enables targeted mRNA delivery, but traditional modification techniques require complex conjugation and purification, which often reduces antibody affinity.
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Efficient mRNA delivery to resting T cells to reverse HIV latency - Nature Communications

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By Paula Cevaal, Bridget Fisher, Michael A Moso, Kiho Tanaka, Rory A. Shepherd, James McMahon Verified, Steven Deeks, Colin W. Pouton, Frank Caruso, Jori Symons, Sharon Lewin
| Nature Verified
Abstract A major hurdle to curing HIV is the persistence of integrated proviruses in resting CD4+ T cells that remain in a transcriptionally silent, latent state. One strategy to eradicate latent HIV is to activate viral transcription, followed by elimination of infected cells through virus-mediated cytotoxicity or immune-mediated clearance.
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Focusing on the fundamentals: what do and don’t we know about mRNA delivery?

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By Colin W. Pouton, Angus Johnston
CP: I am a pharmaceutical scientist by training. What fascinates me most in the mRNA delivery space is the success of lipid nanoparticles (LNPs) and the questions around how they work, what makes them unique, what makes them particularly amenable to manufacturing, and what alternatives there are. We are still at the very early stages of this technology, and—in the public domain, at least—a lot of what I’d consider the core pharmaceutical aspects are still not well known.
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