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Articles by Conor McCafferty
A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines.
Identifying the molecular mechanisms that promote optimal immune responses to COVID-19 vaccination is critical for future rational vaccine design. Here, we longitudinally profile innate and adaptive immune responses in 102 adults after the first, second and third doses of mRNA or adenoviral vectored COVID-19 vaccines.
Uncovering the triggers of severe COVID-19 in kids
In most cases, children are largely protected from severe COVID-19. They have fewer symptoms, less severe disease and tend to recover more quickly than adults. Only 1.7 per cent of children will be hospitalised for COVID-19 – most will have mild or no symptoms. For previously unknown reasons, a small number of children progress to serious disease unlike that seen in adults.
We've pinpointed blood proteins activated in the most severe cases of COVID in children
In the majority of cases, children who catch COVID won’t end up suffering serious illness. Kids have fewer symptoms, less severe disease, and tend to recover faster than adults. The best case scenario for children sees them having relatively manageable symptoms, recovering fully, and soon testing negative. As researchers, we wanted to understand why some children have a far worse experience. If they don’t recover, children with COVID can go on develop two different disorders.
Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis - The Journal of Pediatrics
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 PCA of hemostatic proteins in 40 participants. Figure 2 Heatmap of the 27 differentially expressed hemostatic proteins. Clustering patterns were obtained using a correlation-based distance and complete linkage. Green denotes proteins with decreased expression, red denotes proteins with increased expression.
What problems do you face that digital health could solve?
The Melbourne Children's Campus (Melbourne, VIC, Australia) is at the forefront of paediatric research. With the neverending stream of patients with complex conditions attending clinics and new research discoveries in the making, how does the campus network adapt to overcome challenges and apply research? The answer is Curve Tomorrow , a digital health design agency.
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