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Articles by Conrad Leonard
Explainable machine learning identifies features and thresholds predictive of immunotherapy response
Abstract The identification of reliable predictors for immunotherapy response remains a critical challenge in precision oncology. Here, we integrated patient clinical features with DNA and RNA sequencing data derived from 229 melanoma samples. We use 138 melanoma samples to develop and train machine learning models predicting patient treatment response. Feature selection included a univariate Mann–Whitney U-test screen (p < = 0.05) prior to unique tailoring for each model using SHAP.
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance
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Main text (Cancer Cell 40, 88–102; January 10, 2022) We, the authors of the paper, described features associated with the response to immunotherapy using multi-omics data from patients with melanoma. After publication, we discovered an error in the script used to prepare Table S1, which led to incorrect annotation in the “Status” column. All patients were listed as “Alive” instead of the appropriate “Alive” or “Dead” status.
By Felicity Newell, Peter Johansson, Alexander M. Menzies, James S Wilmott, Venkateswar Addala, Matteo S. Carlino, Helen Rizos, Katia Nones, Jarem J. Edwards, Vanessa Anne Lakis, Stephen H. Kazakoff, Pamela Mukhopadhyay, Peter Ferguson, Conrad Leonard, Lambros T. Koufariotis, Scott Wood, Christian Blank, John Thompson, Andrew Spillane, Robyn Saw, Kerwin Shannon, John Pearson, Nicholas Hayward, Richard A. Scolyer, Nicola Waddell, Georgina V. Long, Graham Mann
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Cell Press
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Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy - Nature Communications
Abstract Oesophageal adenocarcinoma is a poor prognosis cancer and the molecular features underpinning response to treatment remain unclear. We investigate whole genome, transcriptomic and methylation data from 115 oesophageal adenocarcinoma patients mostly from the DOCTOR phase II clinical trial (Australian New Zealand Clinical Trials Registry-ACTRN12609000665235), with exploratory analysis pre-specified in the study protocol of the trial.
streammd: fast low-memory duplicate marking using a Bloom filter
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FLASHBACK FRIDAY: DES RIPS OFF DOOR AFTER HAYNE-LED COMEBACK
Carrying on the theme of Jarryd Hayne week, we’re building up for tonight’s Manly-Parramatta grudge match with one of the former Eels fullback’s most memorable performances.
F*** ME FRIDAY! ALAIN RIOU DEMOLISHED AT TEAHUPO'O
Don’t worry, he’s still alive…we think.
SECOND TEST EVENLY POISED AFTER DAY 1
Desperate to atone for their heavy first-Test defeat, the tourists enjoyed a blistering start as Mitchell Starc removed both openers to leave Sri Lanka reeling at 2/9.
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