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Constantine Bartolutti on Muck Rack

Constantine Bartolutti

As seen in: BioRxiv, Genes and Development Journal
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Articles

UPR deficiency leads to poor growth, aneuploidy, and a trade-off between ER and general proteostasis in yeast

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By Constantine Bartolutti, Allison Kim, Yanzhe Ma, Thiago Fernandes Verified
| Genes and Development Journal
1,5,6 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA; 2Department of Biological Sciences, Columbia University, New York, New York 10027, USA; 3Department of Molecular Genetics, Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; 4RIKEN Center for Sustainable Resource Science, Wako, Saitama 351-0198, Japan; 5California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley,...
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UPR deficiency in budding yeast reveals a trade-off between ER folding capacity and maintenance of euploidy

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By Allison Kim, Gloria A. Brar, Constantine Bartolutti
| BioRxiv
Abstract The Unfolded Protein Response (UPR) was discovered in budding yeast as a mechanism that allows cells to adapt to ER stress. While the Ire1 branch of this pathway is highly conserved, it is not thought to be important for cellular homeostasis in the absence of stress. Surprisingly, we found that removal of UPR activity led to pervasive aneuploidy in budding yeast cells, suggesting selective pressure resulting from UPR-deficiency.
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