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Articles

Identification of methylation-sensitive human transcription factors using meSMiLE-seq

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By Antoni J. Gralak, Katerina Faltejskova, Ally Yang, Clemence Steiner, Julie Russeil, Sachi Inukai, Mustafa Demir, Riccardo Dainese, Cooper Owen, Eugenia V. Pankevich, Timothy Hughes, Ivan V. Kulakovskiy, Judith F. Kribelbauer-Swietek, Guido van Mierlo, Bart Deplancke, Nadia Grenningloh
| Nature Verified
Abstract Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 74 new DNA binding motifs.
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