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Bart Deplancke

As seen in: Nature, BioRxiv, Cell Press, The Journal of Biological Chemistry
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Articles

An expanded codebook of human transcription factor DNA-binding specificity

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By Arttu Jolma, Kaitlin U Laverty, Ali Fathi, Ally Yang, Isaac Yellan, Ilya Vorontsov, Antoni J. Gralak, Judith F. Kribelbauer-Swietek, Sachi Inukai, Rozita Razavi, Mihai Albu, Alexander A. Brechalov, Vladimir Nozdrin, Georgy Meshcheryakov, Andrey Buyan, Ivan Kozin, Sergey A. Abramov, Alexandr Boytsov, Quaid Morris, Matthew T Weirauch, Oriol Fornes, Vsevolod J. Makeev, Jan Grau, Ivo Grosse, Philipp Bucher, Bart Deplancke, Ivan V. Kulakovskiy, Timothy Hughes
| Nature Verified
Abstract Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs1. Furthermore, even for well-characterized TFs, it remains controversial the degree to which motifs accurately reflect binding sites in living cells2.
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Identification of methylation-sensitive human transcription factors using meSMiLE-seq

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By Antoni J. Gralak, Katerina Faltejskova, Ally Yang, Clemence Steiner, Julie Russeil, Sachi Inukai, Mustafa Demir, Riccardo Dainese, Cooper Owen, Eugenia V. Pankevich, Timothy Hughes, Ivan V. Kulakovskiy, Judith F. Kribelbauer-Swietek, Guido van Mierlo, Bart Deplancke, Nadia Grenningloh
| Nature Verified
Abstract Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacterized putative human TFs using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq), revealing 74 new DNA binding motifs.
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Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice

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By Marie Rumpler, Guido van Mierlo, Kasper T. Vinten, Stefan Christen, Faisal Hayat, Mikhail V. Makarov, Vincent Gardeux, Julie Russeil, Bauke V. Schomakers, Clemence Steiner, Judith Giroud-Gerbetant, Magali Joffraud, Sofia Moco, Marie E. Migaud, Riekelt Houtkooper, Bart Deplancke, Maria Pilar Giner, Laurine van Gijn, Horia Hashimi
| Nature Verified
Abstract NAD+ is a crucial metabolic cofactor whose intracellular levels can influence the progression of multiple metabolic and age-related complications. There is therefore a strong interest in using NAD+ precursors (vitamin B3s) as therapeutic tools, but most current precursors exhibit either poor bioavailability or adverse effects.
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