Corinne Collett

Introduction The daily management of glucose levels in type 1 diabetes is challenging. Maintaining safe maternal glycaemia in the postpartum period is complicated by the profound physiological changes that occur after delivery and the lifestyle changes associated with caring for a newborn.

Abstract Hybrid closed-loop insulin therapy has shown promise for management of type 1 diabetes during pregnancy; however, its efficacy is unclear. In this multicenter, controlled trial, we randomly assigned pregnant women with type 1 diabetes and a glycated hemoglobin level of at least 6.5% at nine sites in the United Kingdom to receive standard insulin therapy or hybrid closed-loop therapy, with both groups using continuous glucose monitoring.