Highlights • STK11/KEAP1 co-mutation promotes cell proliferation, independent of KRAS status • NRF2 activity is enhanced in STK11/KEAP1 co-mutation beyond KEAP1 loss alone • STK11 and KEAP1 mutations each independently promote ferroptosis protection • SCD1 protects STK11/KEAP1 co-mutant LUAD from ferroptosis and is essential for survival Summary Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to...
