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Corrin A. Wohlhieter on Muck Rack

Corrin A. Wohlhieter

As seen in: Cell Reports
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

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By Byrne C.J, Allison Richards, Corrin A. Wohlhieter, Fathema Uddin
| Cell Reports Verified
Highlights • STK11/KEAP1 co-mutation promotes cell proliferation, independent of KRAS status • NRF2 activity is enhanced in STK11/KEAP1 co-mutation beyond KEAP1 loss alone • STK11 and KEAP1 mutations each independently promote ferroptosis protection • SCD1 protects STK11/KEAP1 co-mutant LUAD from ferroptosis and is essential for survival Summary Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to...
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