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Articles by Courtney Sutton
"Rescue of Male Infertility by Human PRSS55 in Transgenic Mice Establis" by Courtney M Sutton, Kohei Umezu et al.
Scientific Reports 10.1038/s41598-025-09604-9 Post-print yes Animals, Male, Infertility, Male, Humans, Mice, Transgenic, Mice, Female, Sperm Motility, Serine Endopeptidases, Spermatozoa, Disease Models, Animal, Mice, Knockout, Testis, Contraceptive Agents, Male, Fertility, Reproductive biology, Cell biology, Molecular biology Sutton, Courtney M; Umezu, Kohei; Mashiko, Daisuke; et al., "Rescue of Male Infertility by Human PRSS55 in Transgenic Mice Establishes a Contraceptive Research Model"...
Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model - Scientific Reports
Abstract The development of non-hormonal male contraceptives requires validated preclinical models. This study investigated whether human orthologs of two mouse testis-specific serine proteases, PRSS55 and TMPRSS12, both essential for male fertility in mice, could functionally rescue the infertility phenotypes of their respective knockout mouse lines.
"Reversible Male Contraception by Targeted Inhibition of Serine/Threoni" by Angela F Ku, Kiran L Sharma et al.
Keywords Animals, Humans, Male, Mice, Blood-Testis Barrier, Contraceptive Agents, Male, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Small Molecule Libraries, Testis, Contraception, Structure-Activity Relationship Abstract Men or mice with homozygous serine/threonine kinase 33 (STK33) mutations are sterile owing to defective sperm morphology and motility.
"CUB Domains Are Not Required for OVCH2 Function in Sperm Maturation in" by Katarzyna Kent, Kaori Nozawa et al.
BACKGROUND: Ovochymase 2 (Ovch2) is an epididymis-specific gene that is required for male fertility. While a multitude of reproductive tract-specific genes required for male fertility have been identified, OVCH2 is thus far the first protein required for male fertility that contains Complement C1r/C1s, Uegf, Bmp1 (CUB) domains located in tandem in the C-terminus of the protein.
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis
1 INTRODUCTION Infertility affects 2.5–3.0 million couples in the United States yearly, of which the male factor is causative in 40%−60% of the cases. However, about 30% of male patients seen for primary infertility evaluation are found to have idiopathic impairment of sperm function.1, 2 In these cases, genetic abnormalities are highly suspected, although still not well understood.
Molecular dissection and testing of PRSS37 function through LC–MS/MS and the generation of a PRSS37 humanized mouse model - Scientific Reports
Abstract The quest for a non-hormonal male contraceptive pill for men still exists. Serine protease 37 (PRSS37) is a sperm-specific protein that when ablated in mice renders them sterile. In this study we sought to examine the molecular sequelae of PRSS37 loss to better understand its molecular function, and to determine whether human PRSS37 could rescue the sterility phenotype of knockout (KO) mice, allowing for a more appropriate model for drug molecule testing.
Molecular Dissection and Testing of PRSS37 Function Through Lc-Ms/Ms and the Generation of a PRSS37 Humanized Mouse Model
Keywords Male, Humans, Mice, Animals, Peptide Hydrolases, Chromatography, Liquid, Proteomics, Tandem Mass Spectrometry, Semen, Mice, Transgenic, Mice, Knockout, Endopeptidases, Infertility, Male, Urogenital models, Experimental organisms, Genetic engineering, Mass spectrometry, Proteomic analysis Abstract The quest for a non-hormonal male contraceptive pill for men still exists. Serine protease 37 (PRSS37) is a sperm-specific protein that when ablated in mice renders them sterile.
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