Craig J Benham

Abstract DNA superhelicity and transcription are intimately related because changes to DNA topology can influence gene expression and vice versa. Information is transferred through the modulation of local DNA torsional stress, where the expression of one gene may influence the superhelical level of neighbouring genes, either promoting or repressing their expression. In this work, we introduce a one-dimensional physical model that simulates supercoiling-mediated regulation.

Frederic Chedin‡,§1 and Craig J. Benham§,¶2 ‡Department of Molecular and Cellular Biology, University of California, Davis, California 95616 §Genome Center, University of California, Davis, California 95616 ¶Departments of Mathematics and Biomedical Engineering, University of California, Davis, California 95616 ↵1 To whom correspondence may be addressed. E-mail: flchedin{at}ucdavis.edu. ↵2 To whom correspondence may be addressed. E-mail: cjbenham{at}ucdavis.edu.

Frederic Chedin1* and Craig J Benham2 1Department of Molecular and Cellular Biology, University of California, United States 2University of California, United States ↵* Corresponding author; email: flchedin{at}ucdavis.edu Author contributions: F.C. and C.J.B. conceptualization; F.C. and C.J.B. writing-original draft; F.C. and C.J.B. writing-review and editing.