Cristina Lo Celso

Significance Dual-pulse nucleoside labeling (DPNL) is a widely used experimental technique for measuring cell-cycle dynamics, yet a key control parameter—the waiting time between labeling pulses—is typically chosen heuristically. Using a minimal stochastic model of cell-cycle progression, we show that inference accuracy depends non-monotonically on this waiting time and that an optimal pulse separation generically exists.

Abstract The stretch reflex is a fundamental component of the motor system that orchestrates the coordinated muscle contractions underlying movement. At the heart of this process lie the muscle spindles (MS), specialized receptors finely attuned to fluctuations in tension within intrafusal muscle fibres.