Cui lin Cheng

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description pc29322-sup-0001-Figures.docxWord 2007 document , 511.4 KB Figure S1. Molecular structural formula detail of 35(45,65)-OTM and temperature response mechanism diagram. Figure S2. (a) Test method for shear strength between substrate and coating; (b) Adhension strength of 15 wt% OMs coating with substrate. Figure S3.

1 INTRODUCTION According to the 2020 statistics provided by the International Agency for Research on Cancer, there has been an increasing incidence of cancer each year, constituting a substantial threat to both public health and the economy.1 Current cancer treatment modalities include surgical intervention, chemotherapy and radiation therapy. Additionally, targeted therapy and immunotherapy are emerging as innovative strategies in the battle against cancer.

The dual drugs loaded hydrogel delivery system was constructed with aldehyded pullulan (A-Pul), ?-poly-L-lysine (?-PL), branched polyethyleneimine (BPEI) in aqueous solution by Schiff base reaction. CDDP and DOX were loaded into the network of the hydrogels for combination drug therapy. The gelation time was changed from 40 s to 240 s when the reaction solutions were stored at different temperature.