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Articles by Cuiling Zeng
Retraction Note: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
Retraction to: Nature Cell Biology X:XXXX; https://doi.org/10.1038/s41556-020-0522-z; Article published online XX Month XXXX The Editors have retracted this article. Concerns were raised regarding image similarities within the article in Fig. 1g and Fig. 6i, Fig. 3f, Fig. 3g, and Fig. 6j, Extended Data Fig. 3l and Extended Data Fig. 5g, and anomalies in the source data underlying Fig. 2f and Extended Data Figs.
Expression of Concern for PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma
Original citation: J Clin Invest. 2025;135(20):e191040. https://doi.org/10.1172/JCI191040 Citation for this expression of concern: J Clin Invest. 2026;136(19):e213311. https://doi.org/10.1172/JCI213311 The authors recently alerted the Editors to errors in the source data for Figure 1G and Supplemental Figure 10K as well as errors in the statistical analysis of Figure 2, Q–T and Figure 5R that were identified in response to an institutional mandate for a post-publication audit of the data.
ASB7 promotes osteosarcoma lung metastasis through ubiquitin-mediated degradation of ATF2
Abstract Osteosarcoma is a highly heterogeneous and aggressive malignancy with a strong propensity for metastasis, highlighting the need to define its molecular drivers. Here, we report that ASB7 promotes tumor cell protrusion formation, invasion, migration, and lung metastasis. High expression of ASB7 is correlated with a poor prognosis. ASB7 forms an E3 ubiquitin ligase complex with CUL5 to ubiquitinate ATF2 at K383 and promote its proteasomal degradation.
PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma
Abstract Osteosarcoma is the most common primary malignant bone cancer, characterized by a high incidence of lung metastasis and a lack of therapeutic targets. Here, by combining an in vivo CRISPR activation screen with the interactome of STUB1, a tumor suppressor in osteosarcoma, we identified that myeloid leukemia factor 2 (MLF2) promotes osteosarcoma metastasis. Mechanistically, MLF2 disrupted the interaction between BiP and IRE1α, thereby activating the IRE1α/XBP1-S-MMP9 axis.
Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma - Nature Cell Biology
Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-020-0522-z, published online 1 June 2020. In the version of the article initially published, due to mistakes during figure preparation, Figs. 1f, 5g and 6d contained incorrect or duplicate panels. In the U2OS/MTX300 row of Fig. 1f, the HE image for Vector was the wrong image. In the top row of Fig. 5g, the image for sgSmgGDS #2 (E254K/E256K) was a duplicate of SmgGDS (sg2) in the same row. In the top row of Fig.
Author Correction: Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-020-0522-z, published online 1 June 2020 In the version of this article originally published, one of the grant numbers in the acknowledgements section was incorrect. ‘31571395 to T.K.’ should read ‘81530081 to T.K.’. The error has been corrected in the HTML and PDF versions of the paper. Author information Author notes These authors contributed equally: Dan Liao, Li Zhong, Junqiang Yin.
Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma
Abstract Osteosarcoma is a type of aggressive malignant bone tumour that frequently metastasizes to lungs, resulting in poor prognosis. However, the molecular mechanisms of lung metastasis of osteosarcoma remain poorly understood. Here we identify exon–intron fusion genes in osteosarcoma cell lines and tissues.
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