Tiebang Kang

Abstract Osteosarcoma is a highly heterogeneous and aggressive malignancy with a strong propensity for metastasis, highlighting the need to define its molecular drivers. Here, we report that ASB7 promotes tumor cell protrusion formation, invasion, migration, and lung metastasis. High expression of ASB7 is correlated with a poor prognosis. ASB7 forms an E3 ubiquitin ligase complex with CUL5 to ubiquitinate ATF2 at K383 and promote its proteasomal degradation.

Get full text access Log in, subscribe or purchase for full access. References 1. Padeken, J. ... Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance Nat. Rev. Mol. Cell. Biol. 2022; 23:623-640 2. Haws, S.A. ... 3D genome, on repeat: higher-order folding principles of the heterochromatinized repetitive genome Cell. 2022; 185:2690-2707 3. McCarthy, R.L. ...

In a recent study published in Nature, Huang, Wong and their colleagues identified G2E3 as the major histone H3 lysine 14 mono-ubiquitin (H3K14ub) ligase in mammalian cells.1 By coupling G2E3-dependent H3K14 ubiquitination to the recruitment of SUV39H at pericentromeric chromatin, the authors define a conserved pathway that guides the reassembly of H3K9me3 domains after mitosis and secures the proper compartmentalization of chromatin.