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Cuiying Yi

As seen in: Nature, Cell Reports
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Articles

Subtype-dependent arrestin engagement of the metabotropic glutamate receptors

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By Shuling Lin, Chenhui Zhang, Jiaxin Wei, Shanshan Li, Jie Yu, Jingyi Xu, Kun Chen, Ye Feng, Ziyu Wang, Xiaojing Chu, Cuiying Yi, Limin Ma, Shuo Han, Wenqing Shui, Qiang Zhao, Beili Wu
| Nature Verified
Abstract The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental mechanism modulating excitatory transmission and synaptic plasticity. However, molecular details of arrestin engagement are elusive for these dimeric receptors. Here we report the structures of mGlu5 and mGlu7 bound to β-arrestin 1 (βarr1) and their endogenous agonist glutamate.
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Ligand binding modes of the bitter taste receptor T2R14 and T2R46

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By Qiuxiang Tan, Yu Yu, Kezhen Liu, Shuo Han, Mu Wang, Yuan Wei, Qiuru Chen, Limin Ma, Cuiying Yi, Xiaojing Chu, Beili Wu, Qiang Zhao, Xuteng Han, Yingrong Zhu
| Nature Verified
Abstract Bitter taste receptors (T2Rs) are considered attractive drug targets. However, the ligand recognition and selectivity of these receptors remain elusive, hampering their drug development. Here we present seven structures of human T2R14 and T2R46 in apo or ligand-bound state.
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Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2

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By Yimiao Huang, Limin Ma, Xiaojing Chu, Beili Wu, Qiang Zhao, Shuo Han, Yudun Ke, Cuiying Yi
| Cell Reports Verified
Keywords Structural biology GPCR free fatty acid receptors FFAR1 FFAR2 signaling complex cryo-EM Research topic(s) CP: Molecular biology Introduction Free fatty acids (FFAs) are well known for their diverse effects on many biological progresses, such as metabolism, inflammation, and cardiovascular health.1 Based on the length of the aliphatic tail chain, FFAs are typically classified into three groups: short-chain fatty acids (SCFAs; fewer than 6 carbons), medium-chain fatty acids (MCFAs;...
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