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Cunyan Zhao on Muck Rack

Cunyan Zhao

As seen in: The Journal of Clinical Investigation
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Articles

Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion by suppressing CXCL10 and CD8 + T cell activation

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By Xinchun Zhang, Jinjiang Xue, Cunyan Zhao
| The Journal of Clinical Investigation
Abstract Glioblastomas (GBMs) are highly lethal brain tumors with limited treatment options and resistance to immune checkpoint inhibitors due to their immunosuppressive tumor microenvironment. Here, we identify OLIG2 as a key regulator of immune evasion in GBM stem-like cells, which inhibits CD8+ T cell–dependent antitumor immunity while promoting protumor macrophage polarization.
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