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D. Ryan Ormond

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Articles

Divergent genomic evolution in astrocytomas and oligodendrogliomas

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By Tamrin Chowdhury, C. Mircea S. Tesileanu, Emre Kocakavuk, Kevin Johnson, Joo Ho Lee, Zeynep Erson-Omay, Chaewon Heo, Kenneth Aldape, Samirkumar B. Amin, David Ashley, Floris P. Barthel, Jill S Barnholtz-Sloan, Daniel J. Brat, Andrew Brodbelt, Ana Castro Verified, Elizabeth Claus, Jennifer Connelly, Joseph Costello Verified, Indrani Datta, Carol Elliott, Gaetano Finocchiaro, Pim J French, Hui K. Gan, Luciano Garofano, Anna Golebiewska, Beth Hermes, Chibo Hong, Youri Hoogstrate, Craig M Horbinski, Jason T. Huse, Antonio Iavarone, Cihat Karadag, Mustafa Khasraw, Peter Laviolette, Kay Li, Allison K. Lowman, Hyo-Eun Moon, Nader Sanai, MacLean P. Nasrallah, Bethany Kwan, Marta Padovan, Sun Ha Paek, Laila M. Poisson, Sushant puri, Erica Y. Shen, Shwetal Mehta, Andrew Sloan, Wies R Vallentgoed, Erwin Van Meir, Rachael A. Vaubel, Taylor Wade, Colin Watts, Tobias Weiss, Michael Weller, Pieter Wesseling, Bart Westerman, Gordon Ye, W. K. Alfred Yung, Frederick S. Varn, Roel G. W. Verhaak, Padmaja L. Ghospurkar, Pranav S. Gundla, Mathilde C. M. Kouwenhoven, Katy McCortney, H. K. Ng, D. Ryan Ormond, Annemiek M. E. Walenkamp, Kerryn Westcott
| Nature Verified
Abstract Astrocytomas and oligodendrogliomas are isocitrate dehydrogenase (IDH)-mutant gliomas that most commonly arise in adults under the age of 50 and exhibit variable responses to treatment1,2,3. To understand the genetic drivers of disease progression, here we used whole-genome and whole-exome sequencing to characterize longitudinally collected tumour specimens from 183 patients with IDH-mutant glioma. Samples were collected through the Glioma Longitudinal Analysis (GLASS) Consortium4.
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