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Dafna Bar-Sagi

As seen in: Nature, Cell Press, Molecular Cancer Research
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Articles

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

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By Koelina Ganguly, Keisuke Yamamoto, Jason Rodencal, Joel Encarnacion-Rosado, Douglas E. Biancur, Elaine Lin, Ruohong Wang, Carolina Alcantara Hirsch, Anthony Sorrentino, Paul M. Grandgenett, Michael A Hollingsworth, Miwako Kakiuchi, Richard Possemato, Dafna Bar-Sagi, Mitsuhiro Fujishiro, Alec C. Kimmelman, Albert S. W. Sohn, Elshaddai Z. White
| Nature Verified
Abstract The liver is the primary site of metastasis in pancreatic ductal adenocarcinoma (PDAC), and liver metastases are a major cause of mortality1,2. Nutrient availability in the metastatic niche influences colonization efficiency; however, the metabolic heterogeneity of disseminated tumour cells can also reshape the local microenvironment3,4,5.
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Embracing cancer complexity: Hallmarks of systemic disease

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By Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James DeGregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A. Febbraio, Andres Hidalgo, Mariam Jamal-Hanjani, Johanna A. Joyce, Matthew G. Kaiser, Katja A. Lamia, Jason W. Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan Patel, Sergio A Quezada, Jennifer Wargo, Ashani T Weeraratna, Eileen White, Frank Winkler, John Wood, Karen Vousden, Douglas Hanahan
| Cell Press Verified
PerspectiveVolume 187, Issue 7p1589-1616 1The Francis Crick Institute, London, UK 2Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK 3INSERM U981, Gustave Roussy, Villejuif, France 4AstraZeneca, Cambridge, UK 5Department of Medical Oncology, Gustave Roussy, Villejuif, France 6Paris Saclay University, Kremlin-Bicetre, France 7Laboratory of Integrative Systems Physiology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland...
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Exploiting cancer’s drinking problem: regulation and therapeutic potential of macropinocytosis

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By Joseph Puccini, MIchael Badgley, Dafna Bar-Sagi
| Cell Press Verified
Lewis W.H. Pinocytosis. Bull. Johns Hopkins Hosp. 1931; 49: 17-27 Simanshu D.K. et al. RAS proteins and their regulators in human disease. Cell. 2017; 170: 17-33 Bar-Sagi D. Feramisco J.R. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by RAS proteins. Science. 1986; 233: 1061-1068 DeBerardinis R.J. Chandel N.S. Fundamentals of cancer metabolism. Sci. Adv. 2016; 2e1600200 Commisso C. et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells.
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