Dagim Shiferaw Tadele on Muck Rack

Dagim Shiferaw Tadele

As seen in: Nature, Physical Review B, The Journal of Biological Chemistry
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Articles

Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance

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By Jeff Maltas, Dagim Shiferaw Tadele, Arda Durmaz
| Physical Review B
Viewpoint Drug-Resistance Mutations Find Strength in Small Numbers Published 3 June 2024 A new model, vetted by experiments on lung cancer cells, may help to explain how cancer and other diseases accumulate drug-resistance mutations that can compromise the effectiveness of treatments. See more in Physics Click to Expand Article Text Click to Expand Supplemental Material Click to Expand Click to Expand
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The balance between intrinsic and ecological fitness defines new regimes in eco-evolutionary population dynamics

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By Rowan J Barker-Clarke, Jason Gray, Dagim Shiferaw Tadele, Jeff Maltas
| biorxiv.org
Abstract Selection upon intrinsic fitness differences is one of the most basic mechanisms of evolution, fundamental to all biology. Equally, within macroscopic populations and microscopic environments, ecological interactions influence evolution. Direct experimental evidence of ecological selection between microscopic agents continues to grow.
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Maintaining, masking, and mimicking selection: the interplay of cell-intrinsic and cell-extrinsic effects upon eco-evolutionary dynamics

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By Rowan J Barker-Clarke, Jason Gray, Dagim Shiferaw Tadele, Michael Hinczewski
| biorxiv.org
Abstract Evolution is a stochastic yet inevitable process that lies at the heart of biology yet in the multi-cellular environments within patients, ecological complexities arise via heterogeneity and microenvironments. The interplay of ecology and mutation is thus fundamental to predicting the evolution of complex diseases and engineering optimal treatment solutions.
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