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Daisy Stringfellow

As seen in: Nature
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Articles by Daisy Stringfellow

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

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By Fiona Shilliday, Ginto George, Shintaro Aibara, Santosh Adhikari, Evelyne J. Barrey, Damian C. Crowther, Paige Dickson, Anders Gunnarsson, Heather Harding, Rachael Jetson, Anthony D. Keefe, Jeesoo Kim, Richard Lewis, Usha Narayanan, Katherine Nugai, Dušan Petrovic, Emma Rivers, David Ron, Karl Syson, Lewis Ward, John Yeoman, Yan Yu, Ying Zhang, Alisa Zyryanova, David Baker, Perla Breccia, John E. Linley, Miguel Gancedo-Rodrigo, Syedah Neha Ashraf, Paolo A. Centrella, Diana Gikunju, Marie-Aude Guié, John P. Guilinger, Christopher D. Hupp, Taiana Maia de Oliveira, Jennifer Le-Marshall, Daisy Stringfellow
| Nature Verified
Abstract Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor 2 (eIF2) with GTP. Stress-induced phosphorylation of eIF2 on its α-subunit [eIF2(αP)] inhibits this reaction triggering a protective Integrated Stress Response (ISR).
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