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Shintaro Aibara on Muck Rack

Shintaro Aibara

As seen in: Nature, Science Magazine, BioRxiv, Cell Reports, Cell Press, JoVE- Journal of Visualized Experiments
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Articles

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

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By Fiona Shilliday, Ginto George, Shintaro Aibara, Santosh Adhikari, Evelyne J. Barrey, Damian C. Crowther, Paige Dickson, Anders Gunnarsson, Heather Harding, Rachael Jetson, Anthony D. Keefe, Jeesoo Kim, Richard Lewis, Usha Narayanan, Katherine Nugai, Dušan Petrovic, Emma Rivers, David Ron, Karl Syson, Lewis Ward, John Yeoman, Yan Yu, Ying Zhang, Alisa Zyryanova, David Baker, Perla Breccia, John E. Linley, Miguel Gancedo-Rodrigo, Syedah Neha Ashraf, Paolo A. Centrella, Diana Gikunju, Marie-Aude Guié, John P. Guilinger, Christopher D. Hupp, Taiana Maia de Oliveira, Jennifer Le-Marshall, Daisy Stringfellow
| Nature Verified
Abstract Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor 2 (eIF2) with GTP. Stress-induced phosphorylation of eIF2 on its α-subunit [eIF2(αP)] inhibits this reaction triggering a protective Integrated Stress Response (ISR).
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Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

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By Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko
| BioRxiv
Abstract RNA polymerase II (Pol II) facilitates co-transcriptional splicing by recruiting the U1 small nuclear ribonucleoprotein particle (U1 snRNP) to the nascent transcripts. Here, we report the cryo-electron microscopy structure of a transcribing Pol II-U1 snRNP complex with elongation factors DSIF and SPT6.
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Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk - Nature Communications

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By Vivek Kumar Singh, Yuzuru Itoh, Asem Hassan, Yuko Nobe, Shintaro Aibara, Juni Andréll, Paul C. Whitford, Antoni Barrientos, Masato Taoka
| Nature Verified
Abstract The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications, including aminoacylated CP-tRNAVal. The structure shows how mitoribosomal proteins stabilise binding of mRNA and tRNA helping to align it in the decoding center, whereas the GDP-bound mS29 stabilizes intersubunit communication.
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