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Daiying Zhou on Muck Rack

Daiying Zhou

As seen in: Nature, Frontiers in Physiology
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Articles

ADORA2A activation restores lysosomal function and photoreceptor outer segment degradation in stressed retinal pigment epithelium

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By Daiying Zhou, Mingjuan Wu, Peiling Xie, Yunhao Zhang, Jing Bao, Daodian Tao
| Frontiers in Physiology
Abstract Background: Age-related macular degeneration (AMD) involves early retinal pigment epithelium (RPE) dysfunction and impaired processing of photoreceptor outer segments (POS). We investigated whether ADORA2A regulates post-ingestive POS handling and lysosomal recovery under AMD-relevant stress. Methods: A2E-stressed ARPE-19 cells, primary porcine RPE cells, and a sodium iodate-induced mouse model were studied. ADORA2A was activated with CGS21680 and inhibited with ZM241385.
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Age, estimated basal metabolic rate, and subfoveal choroidal thickness: a cross-sectional study based on cataract patients

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By Yun Wang, Changdong Li, Daiying Zhou
| Nature Verified
Abstract To investigate the relationship between the basal metabolic rate (BMR) and subfoveal choroidal thickness (SFCT) and the statistical mediating role of the BMR in age-related changes in SFCT. This cross-sectional study included 119 cataract surgery patients. BMR was calculated by the Mifflin–St Jeor equation, and SFCT was measured via swept-source OCT and its integrated software.
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