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Daodian Tao on Muck Rack

Daodian Tao

As seen in: Frontiers in Physiology
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Articles

ADORA2A activation restores lysosomal function and photoreceptor outer segment degradation in stressed retinal pigment epithelium

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By Daiying Zhou, Mingjuan Wu, Peiling Xie, Yunhao Zhang, Jing Bao, Daodian Tao
| Frontiers in Physiology
Abstract Background: Age-related macular degeneration (AMD) involves early retinal pigment epithelium (RPE) dysfunction and impaired processing of photoreceptor outer segments (POS). We investigated whether ADORA2A regulates post-ingestive POS handling and lysosomal recovery under AMD-relevant stress. Methods: A2E-stressed ARPE-19 cells, primary porcine RPE cells, and a sodium iodate-induced mouse model were studied. ADORA2A was activated with CGS21680 and inhibited with ZM241385.
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