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Articles by Dan Xia
Pregnant women’s perceived understanding and antenatal information needs regarding newborn screening for inherited metabolic diseases in southwestern China: a cross-sectional study
Abstract Background: Newborn screening (NBS) can reduce morbidity from some inherited metabolic diseases (IMDs) through early detection and timely treatment. Clear antenatal communication can support informed participation and timely follow-up by helping parents understand the purpose and pathway of screening.
AURKB-mediated phosphorylation of metabolic enzyme CD73 drives immune suppression and renal cell carcinoma progression
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Abstract Aberrant tumor metabolism plays a crucial role in establishing and sustaining an immunosuppressive microenvironment. CD73, a key enzyme in the purine metabolism pathway, is frequently overexpressed in tumors, leading to elevated extracellular adenosine (ADO) levels. This accumulation suppresses antitumor immune responses by promoting immune cell exhaustion, ultimately contributing to immunotherapy resistance.
By Tianyu Tang, Wuping Yang, Minghao Lu, Ding Peng, Shiqi Li, Sijia Cui, Jiandong Liu, Yifan Wang Verified, Cunjin Wu, Haojie Huang, Xin Xu, Dan Xia, Yi Zhu, Sunyi Ye, Haoyang Teng
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Nature
Verified
Health education needs of pregnant women regarding newborn inborn errors of metabolism based on a social ecological model: a qualitative study
Abstract Background: This study explored pregnant women's perceptions, experiences, and health education needs regarding newborn inborn errors of metabolism (IEM) and newborn screening, and examined how these needs operate across individual, interpersonal/healthcare-organizational, and community/policy-environment levels. Methods: A descriptive phenomenological qualitative design was used.
Development of an Electro-Responsive Sorafenib-Loaded Polypyrrole Film-Modified Nickel-Titanium Alloy for Tumor Ablation Therapy
You are already at the latest version Nickel-titanium (NiTi) stents have been widely used for the palliative treatment of portal vein tumor thrombi due to their excellent mechanical strength and biocompatibility. However, traditional NiTi implants lack active antitumor functions, which can easily lead to tumor re-invasion and subsequent restenosis.
The Mechanical Properties of 3D Printed Multiscale Hybridized Graphene Oxide and Short Carbon Fiber Reinforced Polyether-Ether-Ketone Composites
, , , , , and , “The Mechanical Properties of 3D Printed Multiscale Hybridized Graphene Oxide and Short Carbon Fiber Reinforced Polyether-Ether-Ketone Composites,” Polymer Composites (2026): 1–14, https://doi.org/10.1002/pc.71324. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared.
Epidemiological profile of respiratory viruses associated with influenza-like illness and severe acute respiratory infection in Guangzhou, China, 2024–2025
Abstract Background: The post-pandemic era has brought about marked shifts in the circulation patterns of respiratory pathogens. Nevertheless, comprehensive epidemiological data on acute respiratory infections (ARIs) covering both influenza-like illness (ILI) and severe acute respiratory infection (SARI) remain scarce for southern China. This study aimed to characterize the epidemiological profiles and pathogen spectra of ARIs in Guangzhou, China, from January 2024 to December 2025.
Frontiers | Association between elevated C-reactive protein-triglyceride-glucose index and in-hospital major adverse cardiovascular events in acute coronary syndrome patients after percutaneous coronary intervention: a single-center prospective observatio
1 Introduction Acute coronary syndrome (ACS) is a group of clinical syndromes characterized by coronary atherosclerotic plaque rupture or erosion leading to thrombus formation, including unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) (1). ACS is one of the leading causes of mortality and disability worldwide.
KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer - Oncogene
Abstract PI3K-AKT signaling axis is often aberrantly activated in human cancers including prostate cancer, but the underlying mechanism of deregulation and tactics for effective targeting of this cancer relevant pathway remain poorly understood. Here, we demonstrate that KBTBD11 E3 ubiquitin ligase gene is frequently deleted in human prostate cancers and that KBTBD11 loss augments AKT phosphorylation in prostate cancer cells in culture and in patient samples.
Optimal Control of Information Dissemination Based on Model‐Free Reinforcement Learning
References 1, , and , “Towards 6G Wireless Communication Networks: Vision, Enabling Technologies, and New Paradigm Shifts,” Science China Information Sciences 64, no. 1 (2021): 5–78. 2, , , , and , “Wireless Communication Technologies for IoT in 5G: Vision, Applications, and Challenges,” Wireless Communications and Mobile Computing 2022 (2022): 1–12.
Halide-ion induced reconstruction of Cu-based catalysts to form stable Cu0/Cu+ sites enabling efficient electroreduction of CO2 to C2+ products
Halide-ion induced reconstruction of Cu-based catalysts to form stable Cu0/Cu+ sites enabling efficient electroreduction of CO2 to C2+ products† Cu-based catalysts are widely employed in the electrocatalytic CO2 reduction reaction (CO2RR) toward multi-carbon (C2+) products due to their unique electronic structures. However, Cu-based catalysts are prone to reconstruction under working conditions.
The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Duan H, Wang T, Zhang X, Xia D, Wang Z, Fong TH, et al. (2025) The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input. PLoS Biol 23(7): e3003272.
De Novo Syntheses of Coumaronochromones: Application in Total Synthesis of Cristatone II
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Carbon-based nanomaterials with greater specific surface area are more expensive but more effective at antimicrobials
Carbon-based nanomaterials with greater specific surface area are more expensive but more effective at antimicrobials Titanium dental implants are prone to infections by pathogenic bacteria, leading to the formation of biofilm and development of peri-implantitis. Carbon-based nanozymes, with their excellent biocompatibility, peroxidase-like activity, and photothermal capabilities, emerge as a low-risk alternative to traditional antibiotics against drug-resistant bacterial infections.
First, to preliminarily clarify the expression patterns of F-box proteins in ccRCC, we obtained the mRNA expression data of 37 proteins from the TCGA-KIRC database and compared their expression differences between ccRCC and adjacent normal (AN) tissues.
Mechanical characterization of 3D printed multiscale carbon nanofiller/continuous fiber reinforced polymer hybrid composites
Supporting Information Filename Description pc29624-sup-0001-supinfo.docxWord 2007 document , 234.5 KB Figure S1. Porosity of extruded (a) CNT/P and (b) GO/P filaments versus the content of CNTs and GO. Figure S2. Porosity of 3D printed CNT/P and GO/P nanocomposite samples versus the content of CNTs and GO. Figure S3. Porosity of 3D printed CBF/CNT/P and CBF/GO/P hybrid CFRPC samples versus the content of CNTs and GO. REFERENCES 1, , .
In vivo and in vitro reconstitution of biosynthesis of N‐prenylated phenazines revealing diverse phenazine‐modifying enzymes
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Rheumatoid arthritis reduces the risk of colorectal cancer through immune inflammation mediation
1 INTRODUCTION Malignancy is a systemic disease characterized by chronic inflammation. Whether this inflammation triggers tumour development or helps tumour growth depends on the overall state of the body.1 But at the same time, in the development of tumours, the immune system also has strong anti-tumour properties.
Gating of Memory to Behavior by the Locus Coeruleus
Abstract An essential function of memory is to guide behavior for survival and adaptation. While considerable knowledge has been accumulated on memory formation, much less is understood about how retrieved memories direct behavior/action.
Hydrodynamics of Butterfly-Mode Flapping Propulsion of Dolphin Pectoral Fins with Elliptical Trajectories
3. Results and Discussion This section focuses on the law of self-propulsion provided by the butterfly flapping mode of the robotic dolphin. As the main propulsion system, A pair of rigid pectoral fins holds three basic attack orientations to perform the flexible butterfly-mode movement. The effective driving force is generated, and the useless span force is balanced.
Development of a Variable-Configuration Bionic Robotic Fish
4. Underwater Experiments and Discussion of Variable-Configuration Robotic Fish 4.1. Construction of the Underwater Test Platform After completing the design of the structure and control system of the machine fish, a set of prototype machines were trial-produced. The experimental study of the propulsion performance of the machine fish was conducted after the commissioning of the underwater environment operation to ensure that the prototype could work properly.
A Comparative and Collaborative Study of the Hydrodynamics of Two Swimming Modes Applicable to Dolphins
Abstract : This paper presents a hydrodynamics study that examines the comparison and collaboration of two swimming modes relevant to the universality of dolphins. This study utilizes a three-dimensional virtual swimmer model resembling a dolphin, which comprises a body and/or caudal fin (BCF) module, as well as a medium and/or paired fin (MPF) module, each equipped with predetermined kinematics.
Dietary glycemic index, glycemic load, and renal cancer risk: findings from prostate, lung, colorectal, and ovarian cancer trial
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Dietary glycemic index, glycemic load, and renal cancer risk: findings from prostate, lung, colorectal, and ovarian cancer trial
1. Introduction Renal cancer currently ranks seventh among the most frequently diagnosed cancer in males and ninth in females (1). In 2020, more than 431,000 cases of renal cancer were projected to occur worldwide (2). The geographic distribution of renal cancer is highest in the Baltic countries and in Eastern European countries and lowest in most parts of Asia and Latin America (3). There is a consistent male to female excess of renal cancer observed in both low- and high-incidence regions (4).
Smart Implant with Bacteria Monitoring and Killing Ability for Orthopedic Applications
Bacterial infections around implants constitute a significant cause of implant failures. Early recognition of bacterial adhesion is an essential factor in preventing implant infections. Therefore, an implant capable of detecting and disinfecting initial bacterial adhesion is required. This study reports on the development of an intelligent solution for this issue.
Dietary Intake of Anthocyanidins and Renal Cancer Risk: A Prospective Study
Abstract : Simple Summary In this large prospective study based on the PLCO trial, both categorical analysis and continuous analysis indicated that higher dietary anthocyanidin consumption was associated with a lower risk of renal cancer. To the best of our knowledge, this is the first prospective study that aimed to explore a potential association between dietary anthocyanidin intake and renal cancer risk.
Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum
Multiple studies have demonstrated the occurrences of short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in environmental matrixes, but human internal exposure to them has been studied rarely.
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