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Dan-Yang Chen

As seen in: Nature, Cell Press
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Articles by Dan-Yang Chen

BDKRB2 upregulation by dystrophic microglia drives pain hypersensitivity in aged mice

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By An Liu, Ming-jun Zhang, Jin-rong Guo, Han Chu, Dan-Yang Chen, Peng Cao, Zhi Zhang, Song-bin Liu, Yuan-zhong Kai
| Nature Verified
Abstract Although pain sensitization is among the most common conditions affecting the elderly, its underlying neural mechanisms remain unclear. Here, we found that mechanical hypersensitivity arises from enhanced glutamatergic excitability in primary somatosensory cortex due to bradykinin receptor B2 (BDKRB2) upregulation by dystrophic microglia during aging.
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Quantum transport in fractal networks - Nature Photonics

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By Xiao-Yun Xu, Xiao-Wei Wang, Dan-Yang Chen, Charles Jayden Smith
| Nature Verified
References 1. Mandelbrot, B. B. Fractals: Form, Chance and Dimension (W. H. Freeman, 1977). 2. ben-Avraham, D. & Havlin, S. Diffusion and Reactions in Fractals and Disordered Systems (Cambridge Univ. Press, 2000). 3. Mandelbrot, B. B. The Fractal Geometry of Nature (W. H. Freeman, 1983). 4. Gouyet, J.-F. Physics and Fractal Structures (Springer, 1996). 5. Ivanov, P. C. et al. Multifractality in human heartbeat dynamics. Nature 399, 461–465 (1999). ADS Article Google Scholar 6. Bandres, M. A., Rechtsman, M. C. & Segev, M.
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Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

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By Cheng-Kun Wang, Nan-Nan Lu, Dan-Yang Chen, Ning-He Sun
| Cell Press Verified
Highlights • Endothelium-derived Sema3G is necessary for synaptic plasticity in the hippocampus • Loss of Sema3G in the vascular endothelium results in behavioral and memory deficits • Sema3G regulates synaptic structure and function via the neuropilin-2/PlexinA4 receptor • Sema3G functionally links the endothelium to signaling cascades activated in neurons Summary The proper interactions between blood vessels and neurons are critical for maintaining the strength of neural circuits and...
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