Dana Boyd Barr
As seen in:
Environmental Health Perspectives,
Nature,
Wiley Online Library,
MDPI,
ACS Publications,
medRxiv
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High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort
Abstract Black and African American women face a dual burden of elevated risk of preterm birth (PTB, <37 weeks of gestation) and exposure to polybrominated diphenyl ethers (PBDE), endocrine-disrupting pollutants. Although prenatal PBDE levels have been linked to PTB, underlying mechanisms remain unclear. We examined serum PBDE levels and metabolomic profiles in 177 pregnant participants (18–40 years old) from the Atlanta African American Maternal-Child Cohort (2014–2019).
Effects of cooking with liquefied petroleum gas versus biomass on hemoglobin concentrations in pregnant women: a pre-specified exploratory analysis of the HAPIN trial
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Abstract Evidence linking household air pollution exposure and blood hemoglobin concentration is lacking. We examine the effect of a liquefied petroleum gas cookstove and fuel intervention on hemoglobin concentration, along with associations between household air pollution exposures and hemoglobin concentration, among pregnant women. We enroll 800 pregnant women each in Guatemala, Peru, India, and Rwanda in an open-label randomized controlled trial (NCT02944682).
By Sheela S Sinharoy, Ajay Pillarisetti, Sant-Rayn Pasricha, Lisa Thompson, Anaite Diaz-Artiga, Usha Ramakrishnan, Ghislaine Rosa, Maggie Clark, Dana Boyd Barr, Kyle Steenland, Lindsay J. Underhill, Miles Kirby, William Checkley, Jennifer L. Peel, Thomas Clasen, Wenlu Ye, Vigneswari Aravindalochanan, Shirin Jabbarzadeh, Amy E. Lovvorn
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Nature
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Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth
Abstract Exposure to tobacco smoke during pregnancy is an established risk factor for early birth including early term birth (ETB) and preterm birth (PTB). However, the underlying molecular mechanisms are minimally understood. In this study, we aimed to characterize the newborn metabolomic associations with early pregnancy maternal tobacco exposure biomarkers and early birth in 269 mother-child pairs in the Atlanta African American Maternal-Child Cohort (2016–2020).
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