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P. Barry Ryan

As seen in: Environmental Health Perspectives, Nature
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Articles

High-resolution metabolomics of maternal polybrominated diphenyl ethers (PBDE) exposure and preterm birth in the Atlanta African American Maternal-Child Cohort

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By Siddhi Desai, Anne L Dunlop, Dana Boyd Barr, Paula-Dene C. Nesbeth, Susan Hoffman, Youran Tan, Mengyuan Ren, Vilinh Tran, Grace Lee, Parinya Panuwet, Stephanie M. Eick, P. Barry Ryan, Dean Jones, Donghai Liang
| Nature Verified
Abstract Black and African American women face a dual burden of elevated risk of preterm birth (PTB, <37 weeks of gestation) and exposure to polybrominated diphenyl ethers (PBDE), endocrine-disrupting pollutants. Although prenatal PBDE levels have been linked to PTB, underlying mechanisms remain unclear. We examined serum PBDE levels and metabolomic profiles in 177 pregnant participants (18–40 years old) from the Atlanta African American Maternal-Child Cohort (2014–2019).
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Newborn metabolomic perturbations associated with prenatal tobacco smoke exposure and early birth

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By Anne L Dunlop, Youran Tan, Dana Boyd Barr, Volha Yakimavets, Parinya Panuwet, Mengyuan Ren, Stephanie M. Eick, Blake Rushing, Susan McRitchie, Susan J. Sumner, P. Barry Ryan, Elizabeth Corwin, Dean Jones, Donghai Liang, Paula-Dene C. Nesbeth, Xiajie Lyu
| Nature Verified
Abstract Exposure to tobacco smoke during pregnancy is an established risk factor for early birth including early term birth (ETB) and preterm birth (PTB). However, the underlying molecular mechanisms are minimally understood. In this study, we aimed to characterize the newborn metabolomic associations with early pregnancy maternal tobacco exposure biomarkers and early birth in 269 mother-child pairs in the Atlanta African American Maternal-Child Cohort (2016–2020).
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Prenatal per- and polyfluoroalkyl substance (PFAS) exposure, metabolomic perturbation, and lower birth weight in African American women: a meet-in-the-middle approach | Environmental Health Perspectives | Vol. 2021, No. 1

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By Dana Boyd Barr, Parinya Panuwet, Che Jung Chang, P. Barry Ryan
| Environmental Health Perspectives Verified
Prenatal per- and polyfluoroalkyl substance (PFAS) exposure, metabolomic perturbation, and lower birth weight in African American women: a meet-in-the-middle approach Abstract BACKGROUND AND AIM: Prenatal exposures to per- and polyfluoroalkyl substances (PFAS) have been linked to restricted fetal growth. Pregnant African American (AA) women are disproportionately exposed to higher levels of select PFAS and experience higher rates of low birth weight than other races/ethnicities.
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