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Dangsheng Li on Muck Rack

Dangsheng Li

Shanghai Shi
As seen in: Nature
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Articles

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

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By Xiao Han, Heng-Ji Xu, Meng-Xia Liu, Yanchen Liu, Yu-Ting Cai, Yu-Sheng Chen, Chun-Chun Gao, Yong-liang Zhao, Xiu-Jie Wang, Dangsheng Li, Xiang Zhou, Ying Yang, Jianyong Han, Yun-Gui Yang, Lin-Fang Ju, Danru Zhang, Shaokang Jia
| Nature Verified
Abstract Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest protein factor regulating developmental cell fate in mammals. Loss of RBBP7 drives cells towards ICM lineage.
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