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Daniel J Kyabayinze

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Articles

Early insights into predicted efficacy of Ebola monoclonal antibodies for the 2026 Bundibugyo virus disease outbreak

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By Gradi Luakanda-Ndelemo, Alisen Ayitewala, Pascal Adroba-Tandele, Andrew Walakira, Adrienne Amuri-Aziza, Daan Jansen, Ronald Galiwango, Eddy Kinganda-Lusamaki, Andrew Tebba, Christian B. Ngandu, Aloysious Ssemaganda, Olivier Tshiani-Mbaya, Stephen Kanyerezi, Judith Kyokushaba, Hellen Rosette Oundo, Servet Kimbonza, Stephen Balinandi, Daniel Mukadi-Bamuleka, Valeria Nakintu, Justus Nsio, Ibrahimm Mugerwa, Daniel Kadobera, Sabue Mulangu, Ahidjo Ayouba, Henry Kyobe Bosa, Misaki Wayengera, Anne W. Rimoin, Benard Lubwama, Atek Kagirita, Steve Ahuka-Mundeke, Dieudonné K. Mwamba, Andrew Kambugu, Pontiano Kaleebu, Christian T. Happi, Laurens Liesenborghs, Miles W Carroll, Piet Maes, Jean B. Nachega, Martine Peeters, Pierre Akilimali, Allan N. Muruta, Jason Kindrachuk, Andrew Rambaut, Daniel J Kyabayinze, Charles Olaro, Koen Vercauteren, Susan Nabadda, Diana Atwine, Daudi Jjingo, Tony Wawina-Bokalanga, Placide Mbala-Kingebeni, Isaac Ssewanyana, Kevin Cissy Nabukeera, Syrus Semawule, Carol Makoha, Daniel Euriene, Micheal Eliu, Sam Gidudu, Ronnie Bahatungire
| Nature Verified
Abstract The 2026 Bundibugyo virus disease (BVD) outbreak in the DRC and Uganda raises urgent questions about the efficacy of existing Ebola virus (EBOV) monoclonal antibodies (mAbs) against Bundibugyo virus (BDBV). Here, we perform genomic and structural analyses of 44 BDBV sequences, including 12 from the 2026 outbreak, to assess mAb binding to the viral glycoprotein (GP).
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Emergence of a Bundibugyo virus variant in the 2026 outbreak in the Democratic Republic of the Congo and Uganda

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By Adrienne Amuri-Aziza, Gradi Luakanda-Ndelemo, Alisen Ayitewala, Daan Jansen, Pascal Adroba-Tandele, Andrew Tebba, Eddy Kinganda-Lusamaki, Stephen Kanyerezi, Pontiano Kaleebu, Christian B. Ngandu, Allan N. Muruta, Daudi Jjingo, Susan Nabadda, Raphael Lumembe-Numbi, Olga Ntumba-Tshitenge, Misaki Wayengera, Ibrahimm Mugerwa, John O. Otshudiema, Judith Kyokushaba, Daniel J Kyabayinze, Uganda Ministry, ACE-Uganda consortium, Henry Kyobe Bosa, Daniel Mukadi-Bamuleka, Charles Olaro, Princesse Paku-Tshambu, Ahidjo Ayouba, Sabue Mulangu, Aloysious Ssemaganda, Nick Loman, Anne W. Rimoin, Atek Kagiria, Samuel W. Wilkinson, Benard Lubwama, Kevin K Ariën, Steve Ahuka-Mundeke, Áine O’Toole, Dieudonné K. Mwamba, Christian T. Happi, Martine Peeters, Laurens Liesenborghs, Piet Maes, Miles W Carroll, Jason Kindrachuk, Pierre Akilimali, Andrew Rambaut, Koen Vercauteren, Tony Wawina-Bokalanga, Isaac Ssewanyana, Placide Mbala-Kingebeni
| Nature Verified
Abstract In May 2026, an outbreak of Ebola disease caused by Bundibugyo virus (BDBV, species Orthoebolavirus bundibugyoense) was declared in the Democratic Republic of the Congo (DRC), with cases originating from DRC and locally transmitted cases reported in Uganda. Bundibugyo virus disease (BVD) outbreaks were previously recorded in 2007-2008 in Bundibugyo District, Uganda, and in 2012 in Isiro, DRC. Here, we generated 22 genomes from samples obtained from individuals with BVD in DRC and Uganda.
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